Description
Product Characteristics:
In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing (1). GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC (2,3). In addition to GABA receptors, several proteins have been identified as regulators of GABA function, including GAD65, GAD67, GABA transporters and GABARAP (GABAA receptor-associated protein) (4-6). GABARAP associates with GABAA Rg2 to link GABAA receptors to the cytoskeleton (6). The GABARAP protein sequence is similar to light chain-3 of microtubule-associated proteins (MAPs) suggesting that it may be a type of MAP or a component of a MAP complex (6).
Synonyms: ATG 8, ATG8, FLC 3A, FLC3A, GABAA receptor associated protein like 2, Gamma aminobutyric acid receptor associated protein like 2, Ganglioside expression factor 2, GATE 16, GATE16, General protein transport factor p16, MAP1 light chain 3 related protein, GABAA receptor-associated protein-like 2, Gabarapl2, Gamma-aminobutyric acid receptor-associated protein-like 2, GATE-16, GBRL2_HUMAN, GEF 2, GEF-2, GEF2, Golgi-associated ATPase enhancer of 16 kDa, MAP1 light chain 3-related protein.
Target Information: Involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity)