Description
Product Characteristics: The antibody TR9 cross-blocks binding of FITC-labeled standard antibody OKM5. CD36 is cell adhesion molecule in platelet in adhesion and aggregation, platelet-monocyte and platelet-tumor cell interation. CD36 is expressed on platelets, macrophages, endothelial cells, early erythroid cells and megakaryocytes. Anti-CD36 antibodies clone TR9, inhibit adhesion function (e.g. adherence of infected erythrocytes to target cells).
Target Information: The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]