Description
Product Characteristics:
Structural Maintenance of Chromosomes (SMC) family proteins play critical roles in various nuclear events that require structural changes of chromosomes, including mitotic chromosome organization, DNA recombination and repair and global transcriptional repression. The chromosome proteins are conserved in eukaryotes lead to mitotic chromosome segregation defects, suggesting a critical function of SMC family proteins in mitotic chromosome dynamics.
Subcellular location: Nucleus
Synonyms: hSMC 5, hSMC5, SMC 5 SMC 5 structural maintenance of chromosomes 5 like 1 SMC5 L1 SMC5 protein SMC5 structural maintenance of chromosomes 5 like 1 SMC5L1 Structural maintenance of chromosomes 5 like 1 Structural maintenance of chromosomes protein 5, SMC5_HUMAN.
Target Information: Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression\, the function seems to be independent of SMC6 (By similarity)