Description
Product Characteristics:
Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production. Tissue specificity, Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and mucosal myeloid cells. Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes. Isoform A.1 and isoform A.2 are expressed in alveolar macrophages, however only one isoform is expressed at alveolar macrophages surfaces.
Subcellular location: Secreted, Cell membrane
Synonyms: CD89, Fc alpha receptor, FCAR, FCAR_HUMAN, IgA Fc receptor, Immunoglobulin alpha Fc receptor.
Target Information: This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]