Description
Product Characteristics:
This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
Subcellular location: Cytoplasm, Cell membrane, Extracellular matrix
Synonyms: B-50, Basp2, GAP-43, Neuromodulin, Axonal membrane protein GAP-43, Calmodulin-binding protein P-57, Growth-associated protein 43, Gap43
Target Information: The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]