Description
Product Characteristics:
This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq].
Subcellular location: Cytoplasm, Nucleus, Cell membrane
Synonyms: Cadherin family member 7, cadherin family member 7 precursor, cadherin ME5, Cadherin related tumor suppressor, Cadherin related tumor suppressor homolog, cadherin related tumor suppressor homolog precursor, Cadherin related tumor suppressor homolog precursor FAT protein homolog, CDHF 7, CDHF7, FAT 1, FAT tumor suppressor 1, FAT tumor suppressor homolog 1, FAT1, hFat 1, hFAT, hFat1, homolog of Drosophila FAT protein, homolog of Drosophila FAT protein precursor, homolog of Drosophila tumor suppressor FAT precursor, ME 5, ME5, Protein fat homolog.
Target Information: The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]