Description
Product Characteristics:
A chromosomal aberration involving MLLT10 is associated with acute leukemias. Translocation t(10,11)(p12,q23) with MLL/HRX. The result is a rogue activator protein.A chromosomal aberration involving MLLT10 is associated with diffuse histiocytic lymphomas. Translocation t(10,11)(p13,q14) with PICALM.
Subcellular location: Nucleus
Synonyms: AF 10, AF10, AF10_HUMAN, ALL 1 fused gene from chromosome 10, ALL1 fused gene from chromosome 10, ALL1-fused gene from chromosome 10 protein, MLLT 10, MLLT10, Myeloid/lymphoid or mixed lineage leukemia trithorax homolog Drosophila translocated to 10, Myeloid/lymphoid or mixed lineage leukemia translocated to 10, Protein AF 10, Protein AF-10, Protein AF10, Type I AF10 protein.
Target Information: This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]