Description
Product Characteristics:
Big Endothelin-1 is precursor of endothelin 1. Big endothelin-1 is cleaved to yield endothelin-1 via the activity of an endothelin-converting enzyme (ECE). Big Endothelin-1 can be hydrolyzed by chymase to generate endothelin 1 (1-21) in vitro. Endothelins are endothelium-derived vasoconstrictor peptides.
Subcellular location: Secreted
Synonyms: EDN1_HUMAN, Big endothelin 1, EDN 1, EDN1, EDN1 protein, Endothelin1, Endothelin 1, Endothelin-1, ET 1, ET1, OTTHUMP00000039245, PPET1,
Target Information: The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]