Description
Product Characteristics:
12 Lipoxygenase is a non heme iron containing dioxygenase which stereospecifically incorporates molecular oxygen into cis,cis-1,4-pentadiene containing polyunsaturated fatty acids. Murine leukocyte 12 Lipoxygenase oxidizes arachidonic acid to 12(S)-HpETE and 15(S)-HpETE in a ratio of 3:1. Murine leukocyte 12 Lipoxygenase is a 75 kDa protein which is 58 % homologous to murine platelet 12 Lipoxygenase, and 70 % homologous to porcine leukocyte 12 Lipoxygenase.
Subcellular location: Cytoplasm
Synonyms: 12 Lox, 12S lipoxygenase, 12S LOX, Alox 12, Alox12, Alox12L, Alox15, Arachidonate 12 lipoxygenase 12S type, Arachidonate 12 lipoxygenase, Arachidonate 12 lipoxygenase leukocyte type, Arachidonate 12 lipoxygenase, 12S type, Arachidonate 12 lipoxygenase, leukocyte type, EC1.13.11.31, LOG 12, LOG12, Platelet type 12 lipoxygenase, Platelet type lipoxygenase 12, P-12-LOX.
Target Information: Oxygenase and 14,15-leukotriene A4 synthase activity