Description
Product Characteristics: This antibody recognizes CD62L, known as L-selectin, a 76 kDa molecule which is a member of the selectin family of adhesion receptors. These function in leucocyte binding to activated endothelium and in lymphocyte homing to high endothelial venules. The antigen is expressed on neutrophils, monocytes, T and B lymphocyte subsets and NK cells. CD62L on neutrophils, but not on lymphocytes, carries the carbohydrate structure sialyl-Lewis X. This carbohydrate is ligand for the selectins P-selectin (CD62P) and E-selectin (CD62E) which can be expressed on endothelial cells, and the interaction of CD62L with these selectins has been argued to play a role in the initial adhesion of neutrophils to endothelium.
Target Information: This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]