Description
Product Characteristics:
Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation.Tissue specificity:Expressed most abundantly in ovary and, at lower levels, in prostate, spleen and testis. Weak expression, if any, in thymus, small intestine, colon and peripheral blood leukocytes.
Subcellular location: Cytoplasm, Nucleus
Synonyms: Zinc finger MIZ domain-containing protein 1, MIZ, PIAS like protein hZimp10, PIAS like protein on chromosome 10, PIAS like protein Zimp10, PIAS-like protein Zimp10, RAI 17, RAI17, RAI-17, Retinoic acid induced 17, Retinoic acid induced protein 17, Retinoic acid-induced protein 17, TRAFIP10, Zimp10, Zinc finger containing Miz1 PIAS like protein on chromosome 10, Zinc finger MIZ domain-containing protein 1, Zinc finger MIZ-type containing 1, Zmiz1, ZMIZ1_HUMAN, hZIMP10, KIAA1224.
Target Information: This gene encodes a member of the PIAS (protein inhibitor of activated STAT) family of proteins. The encoded protein regulates the activity of various transcription factors, including the androgen receptor, Smad3/4, and p53. The encoded protein may also play a role in sumoylation. A translocation between this locus on chromosome 10 and the protein tyrosine kinase ABL1 locus on chromosome 9 has been associated with acute lymphoblastic leukemia. [provided by RefSeq, Mar 2010]