Description
Product Characteristics:
May play a role in transcriptional regulation. Component of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor b (P-TEFb).
Subcellular location: Nucleus
Synonyms: Alf4, Laf4, MGC107469, AF4/FMR2 family member 4, AF5Q31, ALL1 fused gene from chromosome 5q31, HSPC092, Lymphoid nuclear protein related to AF4 like, Major CDK9 elongation factor associated protein, MCEF, RP23-226J16.7, AFF4_HUMAN.
Target Information: The protein encoded by this gene belongs to the AF4 family of transcription factors involved in leukemia. It is a component of the positive transcription elongation factor b (P-TEFb) complex. A chromosomal translocation involving this gene and MLL gene on chromosome 11 is found in infant acute lymphoblastic leukemia with ins(5\,11)(q31\,q31q23). [provided by RefSeq, Oct 2011]