Description
Product Characteristics:
Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.
Subcellular location: Cell membrane
Synonyms: Kcnd1, KCND1_HUMAN, Kv4.1, mShal, Potassium voltage gated channel Shal related subfamily member 1, Potassium voltage gated channel subfamily D member 1, Potassium voltage-gated channel subfamily D member 1, Shal type potassium channel, Voltage gated potassium channel Kv4.1, Voltage gated potassium channel subunit Kv4.1, Voltage-gated potassium channel subunit Kv4.1.
Target Information: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This gene is expressed at moderate levels in all tissues analyzed, with lower levels in skeletal muscle. [provided by RefSeq, Jul 2008]