Description
Product Characteristics:
SCRG1 (scrapie-responsive protein 1) is a 98 amino acid secreted protein that belongs to the SCRG1 family. The SCRG1 protein contains a 20-amino acid signal peptide, and is expressed abundantly in the central nervous system of human adult, but not at all in fetal brain. The protein is targeted to the Golgi apparatus and large dense-core vesicles/secretory granules in neurons. High levels of SCRG1 transcripts are also observed in testis and aorta. SCRG1 is associated with neurodegenerative changes observed in transmissible spongiform encephalopathies. It may play a role in host response to prion-associated infections. The SCRG1 protein may be partly included in the membrane or secreted by the cells due to its hydrophobic N-terminus. The human and mouse SCRG1 proteins share 83 % sequence identity. The SCRG1 gene is conserved in chimpanzee, cow, mouse, rat and chicken, and maps to human chromosome 4q34.1.
Synonyms: Developmental Pluripotency Associated 2, developmental pluripotency associated gene2, PESCRG1, Pluripotent embryonic stem cell related protein 1, cancer/testis antigen 100, CT100, developmental pluripotency-associated gene 2, developmental pluripotency-associated protein 2, ECAT15-2, embryonic stem cell ESC associated transcript 15-2, PESCRG1, Pluripotent embryonic stem cell related protein 1, Pluripotent embryonic stem cell-related gene 1, Pluripotent embryonic stem cell-related gene 1 protein.
Target Information: Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in the maintenance of the active epigenetic status of these genes (By similarity)