Description
Product Characteristics:
Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. PILRB is the non-ITIM-bearing member of the receptor pair, which has a truncated cytoplasmic tail relative to its ITIM-bearing partner and functions in the activating role. There are three named isoforms produced by alternative splicing.
Subcellular location: Cell membrane
Synonyms: Paired immunoglobulin-like type 2 receptor beta, Activating receptor PILR beta, Cell surface receptor FDFACT, Cell surface receptor FDFACT1, Cell surface receptor FDFACT2, FDFACT, FDFACT1, FDFACT2, PILR_, Paired immunoglobulin like receptor beta, Paired immunoglobulin like type 2 receptor beta, Paired immunoglobulin like type 2 receptor beta precursor.
Target Information: The paired immunoglobin-like type 2 receptors consist of highly related activating and inhibitory receptors that are involved in the regulation of many aspects of the immune system. The paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This gene encodes the activating member of the receptor pair and contains a truncated cytoplasmic tail relative to its inhibitory counterpart (PILRA), that has a long cytoplasmic tail with immunoreceptor tyrosine-based inhibitory (ITIM) motifs. This gene is thought to have arisen from a duplication of the inhibitory PILRA gene and evolved to acquire its activating function. Alternatively spliced transcript variants have been noted for this gene, but the full-length nature of many is not known. [provided by RefSeq, Nov 2012]