Description
Product Characteristics:
Alpha-1-antitrypsin is a protease inhibitor, deficiency of which is associated with emphysema and liver disease. The protein is encoded by a gene (PI) located on the distal long arm of chromosome 14.
Subcellular location: Secreted, Extracellular matrix
Synonyms: Tryptase, Alpha-1-Antitrypsin, alpha 1 Antitrypsin, A1A, A1AT, AAT, Alpha 1 antiproteinase, Alpha 1 antitrypsin, Alpha 1 protease inhibitor, alpha-1-AT, alpha1 PI, alpha1 proteinase inhibitor, Clade A alpha 1 antiproteinase antitrypsin member 1, MGC23330, MGC9222, PI, PI, PRO2275, Protease inhibitor 1 anti elastase, Serpin A1, Serpin peptidase inhibitor clade A alpha 1 antiproteinase antitrypsin member 1, SerpinA1, A1AT_HUMAN, Alpha-1-antitrypsin, Alpha-1 protease inhibitor, Alpha-1-antiproteinase, Serpin A1.
Target Information: The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]