Description
Product Characteristics:
The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008].
Subcellular location: Cytoplasm, Nucleus
Synonyms: IMDH1_HUMAN, IMP inosine monophosphate dehydrogenase 1, IMP dehydrogenase 1, IMPD 1, IMPD, IMPD1, IMPDH 1, IMPDH I, IMPDH-I, Impdh1, Inosine 5' monophosphate dehydrogenase 1, Inosine monophosphate dehydrogenase 1, Inosine-5''-monophosphate dehydrogenase 1, Inosine-5'-monophosphate dehydrogenase 1, LCA11, RP10.
Target Information: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors (By similarity)