Description
Product Characteristics:
Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Binds phosphatidyl inositol phosphates (in vitro). May catalyze the transfer of phosphatidylinositol and phosphatidylcholine between membranes (By similarity). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium ions.
Subcellular location: Cytoplasm, Cell membrane
Synonyms: membrane-associated 1, DRES9, Drosophila retinal degeneration B, Drosophila retinal degeneration B homolog, Membrane-associated phosphatidylinositol transfer protein 1, NIR 2, NIR-2, NIR2, Phosphatidylinositol transfer protein, phosphatidylinositol transfer protein membrane associated, phosphatidylinositol transfer protein membrane-associated, PITM1_HUMAN, PITPnm 1, PITPNM, Pitpnm1, PYK2 N terminal domain interacting receptor 2, PYK2 N-terminal domain-interacting receptor 2, RD 9, RD9, RDGB, RDGB1, RDGBA1, retinal degeneration B alpha 1.
Target Information: PITPNM1 belongs to a family of membrane-associated phosphatidylinositol transfer domain-containing proteins that share homology with the Drosophila retinal degeneration B (rdgB) protein (Ocaka et al., 2005 [PubMed 15627748]).[supplied by OMIM, Mar 2008]