Description
Product Characteristics:
A novel cyclin-dependent kinase-related molecule, NKIAMRE, has been identified that is thought to be a tumor suppressor locus. The NKIAMRE gene is located on chromosome 5q, a region that is often deleted in human acute leukemia and human myeloid dysplastic disorders.
Subcellular location: Cytoplasm
Synonyms: CDKL3 protein, Cyclin dependent kinase like 3, CDKL3_HUMAN.
Target Information: The protein encoded by this gene is a member of cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This gene was identified as a gene absent in leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]