Description
Product Characteristics:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
Subcellular location: Cytoplasm, Nucleus
Synonyms: ERK 1, ERK 2, ERK-2, ERK1, ERK2, ERT1, ERT2, Extracellular signal regulated kinase 1, Extracellular signal regulated kinase 1, Extracellular signal regulated kinase 2, Extracellular signal regulated kinase 2, Extracellular signal-regulated kinase 2, HS44KDAP, HUMKER1A, Insulin stimulated MAP2 kinase, MAP kinase 1, MAP kinase 2, MAP kinase isoform p42, MAP kinase isoform p44, MAPK 1, MAPK 2, MAPK1, MAPK2, MGC20180, Microtubule associated protein 2 kinase, Mitogen activated protein kinase 1, Mitogen activated protein kinase 1, Mitogen activated protein kinase 2, Mitogen-activated protein kinase 1, Mitogen-activated protein kinase 2, MK01_MOUSE, p38, p40, p41, p41mapk, p42 MAPK, p42-MAPK, p42MAPK, p42MAPK, p44 ERK1, p44 MAPK, p44ERK1, p44ERK1, p44MAPK, p44MAPK, PRKM 1, PRKM 1, PRKM 2, PRKM 2, PRKM1, PRKM2, Protein kinase mitogen activated 1, Protein kinase mitogen activated 1, Protein kinase mitogen activated 2, Protein kinase mitogen activated 2, Protein tyrosine kinas.
Target Information: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008]