Description
Product Characteristics:
This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq].
Subcellular location: Nucleus
Synonyms: inhibitor of growth gene 1, Growth inhibitor ING 1, Growth inhibitor ING1, Growth inhibitory protein ING 1, Growth inhibitory protein ING1, Homo sapiens growth inhibitor p33ING1 ING1 mRNA, complete cds, ING 1, Inhibitor of growth 1, Inhibitor of growth family member 1, Inhibitor of growth protein 1, p24ING1c, p33, p33 ING1, p33ING1, p33ING1b, p47, p47ING1a, Tumor suppressor ING 1, Tumor suppressor ING1.
Target Information: This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]