Description
Product Characteristics:
SLC37A4 transports glucose-6-phosphate from the cytoplasm to the lumen of the endoplasmic reticulum. It forms a complex with glucose-6-phosphatase which is responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it plays a central role in homeostatic regulation of blood glucose levels.
Subcellular location: Cytoplasm, Cell membrane
Synonyms: G6PT2, GSD1b, GSD1c, GSD1d, TRG19, G6PT1, G6PT3, Glucose-5-phosphate transporter, Glucose-6-phosphatase, transport glucose protein 3 antibody, Glucose-6-phosphatase, transport glucose-6-phosphate protein 1, Glucose-6-phosphatase, transport phosphate/pyrophosphate protein 2, Glucose-6-phosphate translocase, Glucose-6-phosphate transporter 1, Microsomal glucose-6-phosphate transporter, Solute carrier family 37 glucose-6-phosphate transporter, member 4, MGC15729, PRO0685, G6PT1_HUMAN.
Target Information: This gene regulates glucose-6-phosphate transport from the cytoplasm to the lumen of the endoplasmic reticulum, in order to maintain glucose homeostasis. It also plays a role in ATP-mediated calcium sequestration in the lumen of the endoplasmic reticulum. Mutations in this gene have been associated with various forms of glycogen storage disease. Alternative splicing in this gene results in multiple transcript variants.[provided by RefSeq, Aug 2009]