Description
Product Characteristics:
The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization.
Subcellular location: Cytoplasm, Nucleus
Synonyms: 80 kDa MCM3 associated protein, 80 kDa MCM3-associated protein, Germinal center associated nuclear protein, KIAA0572, MAP80, MCM3 import protein, MCM3 minichromosome maintenance deficient 3 S. cerevisiae associated protein, MCM3 minichromosome maintenance deficient 3 associated protein, MCM3A, MCM3A_HUMAN, MCM3AP, Minichromosome maintenance complex component 3 associated protein, Minichromosome maintenance deficient 3 associated protein, Minichromosome maintenance protein 3 associated protein, Protein GANP.
Target Information: The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization. [provided by RefSeq, Jul 2008]