Description
Product Characteristics:
Act as a repressor of nuclear receptor-dependent transcription possibly by interfering with CREBBP-dependent coactivation. May function as a coinhibitor of other CREBBP/EP300-dependent transcription factors.Tissue specificity: Highly expressed in testis.
Subcellular location: Cytoplasm, Nucleus
Synonyms: E1A-like inhibitor of dferentiation 3, EID 3, EID-1-like inhibitor of dferentiation 3, EID-3, EID3, EID3_HUMAN, EP300 interacting inhibitor of dferentiation 3, EP300-interacting inhibitor of dferentiation 3, Non-SMC element 4, S. cerevisiae, homolog of, B, NSE4B, NSMCE4B.
Target Information: Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity). Act as a repressor of nuclear receptor-dependent transcription possibly by interfering with CREBBP-dependent coactivation. May function as a coinhibitor of other CREBBP/EP300- dependent transcription factors (By similarity)