Description
Product Characteristics:
The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.
Subcellular location: Cytoplasm, Cell membrane
Synonyms: PAK1Thr212, PAK1phospho T212, Alpha PAK, Alpha-PAK, MGC130000, MGC130001, p21 activated kinase 1, p21 protein Cdc42/Rac activated kinase 1, p21-activated kinase 1, p21/Cdc42/Rac1 activated kinase 1 yeast Ste20 related, p21/Cdc42/Rac1 activated kinase 1, p21/Cdc42/Rac1-activated kinase 1 STE20 homolog, yeast, p65 PAK, p65-PAK, PAK alpha, PAK-1, Pak1, PAK1_HUMAN, Paka, PAKalpha, Protein kinase MUK2, Rac/p21-activated kinase, Serine/threonine-protein kinase PAK 1, STE20 homolog yeast, STE20 homolog yeast.
Target Information: This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]