Description
Product Characteristics:
Essential for the control of the cell cycle at the G2/M (mitosis) transition.
Subcellular location: Cytoplasm, Nucleus
Synonyms: HsT17299, G2/mitotic-specific cyclin-B2, CCNB2
Target Information: Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control. [provided by RefSeq, Jul 2008]