Description
Product Characteristics:
Has E3 ubiquitin protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Has anti-apoptotic activity. May bind phosphatidylinositol phosphates.
Subcellular location: Cytoplasm, Cell membrane
Synonyms: CARP-2, CARP2, Caspase regulator CARP2, Caspases 8 and 10 associated RING finger protein 2, Caspases-8 and -10-associated RING finger protein 2, E3 ubiquitin protein ligase rylin, E3 ubiquitin-protein ligase rylin, Fring, FYVE RING finger protein Sakura, FYVE-RING finger protein Sakura, Rffl, RFFL_HUMAN, Rylin, RING finger and FYVE like domain containing protein, RING finger and FYVE-like domain-containing protein 1, RING finger protein 189, RING finger protein 34 like, RING finger protein 34-like, RNF189, RNF34L.
Target Information: Has E3 ubiquitin protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Has anti-apoptotic activity. May bind phosphatidylinositol phosphates (By similarity). Overexpression slows protein traffic through recycling endosomes