Description
Product Characteristics:
WNK1 controls sodium and chloride ion transport by inhibiting the activity of WNK4, potentially by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide sensitive Na/Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization.
Subcellular location: Cytoplasm
Synonyms: Erythrocyte 65 kDa protein, HSAN2, HSN2, hWNK1, KDP, KIAA0344, Kinase deficient protein, MGC163339, MGC163341, p65, PRKWNK1, Prostate derived sterile 20 like kinase, Protein kinase lysine deficient 1, Protein kinase lysine-deficient 1, Protein kinase with no lysine 1, PSK, Serine/threonine protein kinase WNK1, Serine/threonine-protein kinase WNK1, With no K, WNK lysine deficient protein kinase 1, WNK1, WNK1_HUMAN.
Target Information: This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010]