Description
Product Characteristics:
May act as receptor for class I MHC antigens.
Subcellular location: Cell membrane
Synonyms: LIR8, CD85C, LIR-8, Leukocyte immunoglobulin-like receptor subfamily B member 5, CD85 antigen-like family member C, Leukocyte immunoglobulin-like receptor 8, LILRB5
Target Information: This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Several other LIR subfamily B receptors are expressed on immune cells where they bind to MHC class I molecules on antigen-presenting cells and inhibit stimulation of an immune response. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]