Description
Product Characteristics:
Involved in cell adhesion. Binds to CD166.
Subcellular location: Extracellular
Synonyms: TP120, T-cell differentiation antigen CD6, T12, CD6
Target Information: This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]