Description
Product Characteristics:
In cooperation with other chaperones, Hsp7s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell.
Subcellular location: Cytoplasm
Synonyms: HSP72, HSPA1, HSP7I, HSP7-1, HSP7-1A, HEL-S-13, Heat shock 7 kDa protein 1A/1B, Heat shock 7 kDa protein 1/2, HSP7-1/HSP7-2, HSP7.1/HSP7.2, HSPA1A, HSX7
Target Information: heat shock protein\, may have an important role following forebrain ischemia and may allow astrocytes to protect neurons [RGD, Feb 2006]