Description
Product Characteristics:
OVCA1 is required for the first step in the synthesis of diphthamide, a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2, MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. OVCA1 is one of several enzymes involved in synthesis of diphthamide in EEF2.
Synonyms: Candidate tumor suppressor in ovarian cancer 1, Diphthamide biosynthesis protein 1, Diphthamide biosynthesis protein 2 homolog like 1, Diphthamide biosynthesis protein 2 like, Diptheria toxin resistance protein required for diphthamide biosynthesis Saccharomyces like 1, Diptheria toxin resistance protein required for diphthamide biosynthesis like 1, DPH like 1 S. cerevisiae, DPH like 1, DPH1, DPH1 homolog S. cerevisiae, DPH1 homolog, DPH2 like 1, DPH2L, DPH2L1, HsDph1, Ovarian cancer associated gene 1, Ovarian cancer associated gene 1 protein, Ovarian tumor suppressor candidate 1, DPH1_HUMAN.
Target Information: Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2\, MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH1 is 1 of several enzymes involved in synthesis of diphthamide in EEF2 (Liu et al., 2004 [PubMed 15485916]).[supplied by OMIM, Mar 2008]