Description
Product Characteristics:
S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene.
Subcellular location: Nucleus
Synonyms: GATAGATA 3 binding protein G3B, GATA-3-binding protein G3B, HUMHOXY 1, HUMHOXY1, Lysine N methyltransferase 8, Lysine N-methyltransferase 8, MTB ZF, MTB-ZF, MTE binding protein, MTE-binding protein, PR domain containing 2 with ZNF domain, PR domain containing protein 2, PR domain zinc finger protein 2, PR domain-containing protein 2, PR-domain zinc finger protein 2, PRDM 2, PRDM2, PRDM2_HUMAN, Retinoblastoma protein binding zinc finger protein, Retinoblastoma protein interacting zinc- inger protein, retinoblastoma protein-interacting zinc finger protein, Retinoblastoma protein-interacting zinc-finger protein, RIZ 1, RIZ 2, RIZ, RIZ-LSB, RIZ1, RIZ2, Zinc finger DNA binding protein, Zinc finger protein RIZ.
Target Information: This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]