Description
Product Characteristics:
NCoR2_Nuclear receptor corepressor 2_mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors.
Subcellular location: Nucleus
Synonyms: Nuclear receptor corepressor 2, N-CoR2, Silencing mediator of retinoic acid and thyroid hormone receptor, SMRT, Thyroid- retinoic-acid-receptor-associated corepressor, T3 receptor-associating factor, TRAC, CTG repeat protein 26, SMAP270.
Target Information: This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]