Description
Product Characteristics:
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. [provided by RefSeq, Jul 2008].
Subcellular location: Cell membrane
Synonyms: IGF-1R Tyr1165/Tyr1166, IGF1R phospho Y1165+Y1166, IGF1R phospho Tyr1165+Tyr1166, p-IGF1R Tyr1165+Tyr1166, CD221, CD221 antigen, IGF 1 receptor, IGF 1R, IGF I receptor, IGF1R, IGFIR, IGFIRC, Insulin like growth factor 1 receptor, Insulin like growth factor 1 receptor precursor, JTK13, MGC142170, MGC142172, IGF1 Receptor, IGF1R_HUMAN.
Target Information: This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. [provided by RefSeq, Jul 2008]