Description
Product Characteristics:
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed, however, it is now believed that there is only one type 1 receptor gene in humans. At least five transcript variants have been described for this gene. Additional variants have been described but their full-length nature has not been determined. The entire coding sequence is contained in the terminal exon and is present in all transcript variants. [provided by RefSeq].
Subcellular location: Cell membrane
Synonyms: AG2S, Agtr 1, Agtr1, Agtr1a, AGTR1B, Angiotensin II receptor type 1, Angiotensin II type 1 receptor, AT-1B, AT-1r, AT1, At1a, AT1AR, AT1B, AT1BR, AT2R1, AT2R1A, AT2R1B, HAT1R, Type 1 angiotensin II receptor, AGTR1_HUMAN, Type-1 angiotensin II receptor, Angiotensin II type-1 receptor, AT1R, Ang II, Angiotensin II receptor type 1, Angiotensin II type 1 receptor, Angiotensin receptor 1, Angiotensin receptor 1B, AT 1B, AT1, AT1R.
Target Information: Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed\, however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012]