Description
Product Characteristics:
Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.
Subcellular location: Cytoplasm
Synonyms: Nfm, Nef3, Neurofilament medium polypeptide, NF-M, 16 kDa neurofilament protein, Neurofilament 3, Neurofilament triplet M protein, Nefm
Target Information: Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]