Description
Product Characteristics:
Inhibits CASP1/caspase-1-dependent IL1B secretion and PYCARD-mediated apoptosis, but not that induced by FAS or BID.Tissue specificity: Widely expressed with highest levels in heart, brain and skeletal muscle.
Subcellular location: Cytoplasm, Cell membrane
Synonyms: CLR11.1, NACHT, leucine rich repeat and PYD containing 10, NACHT, LRR and PYD domains containing protein 10, NACHT, LRR and PYD domains-containing protein 10, NAL10_HUMAN, NALP10, NLR family, pyrin domain containing 10, Nlrp10, NOD8,Nucleotide-binding oligomerization domain protein 8, Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 10, PAN5, PYNOD.
Target Information: Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis