Description
Product Characteristics:
Modulator of beta-cells function, acting through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose.
Subcellular location: Cell membrane
Synonyms: B lymphocyte kinase, B lymphoid tyrosine kinase, Blk, BLK nonreceptor tyrosine kinase, BLK_HUMAN, MODY 11, MODY11, P55 BLK, p55-BLK, Tyrosine kinase B lymphocyte specic, Tyrosine protein kinase, Tyrosine-protein kinase BLK.
Target Information: This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors. [provided by RefSeq, Aug 2010]