Description
Product Characteristics:
SLC25A13 is a member of the mitochondrial carrier family. It contains four EF-hand Ca(2+) binding motifs in the N-terminal domain, and localizes to mitochondria. It catalyzes the exchange of aspartate for glutamate and a proton across the inner mitochondrial membrane, and is stimulated by calcium on the external side of the inner mitochondrial membrane. Mutations in the SLC25A13 gene result in citrullinemia, type II. Multiple transcript variants encoding different isoforms have been found for this gene.
Subcellular location: Cytoplasm, Cell membrane
Synonyms: ARALAR2, Calcium binding mitochondrial carrier protein Aralar2, Citrin, CTLN2, Ctrn, Mitochondrial aspartate glutamate carrier 2, RGD1565889, Solute carrier family 25 citrin member 13, Solute carrier family 25 member 13 citrin, Solute carrier family 25 member 13, AI785475, CMC2_HUMAN.
Target Information: This gene is a member of the mitochondrial carrier family. The encoded protein contains four EF-hand Ca(2+) binding motifs in the N-terminal domain, and localizes to mitochondria. The protein catalyzes the exchange of aspartate for glutamate and a proton across the inner mitochondrial membrane, and is stimulated by calcium on the external side of the inner mitochondrial membrane. Mutations in this gene result in citrullinemia, type II. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]