Description
Product Characteristics:
Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle.
Subcellular location: Nucleus
Synonyms: TBP Associated Factor 1, BA2R, CCG 1, CCG1, CCGS, Cell cycle G1 phase defect, Cell cycle gene 1 protein, Complementation of cell cycle block G1 to S, DYT3 protein, NSCL 2, NSCL2, OF, p250, TAF 1, TAF 2A, TAFII250, TAF1, TAF1 RNA polymerase II TATA box binding protein TBP associated factor 250 kDa, TAF1 RNA polymerase II TATA box binding protein TBP associated factor, TAF1 RNA polymerase II TATA box binding protein associated factor 250 kDa, TAF1_HUMAN, TAF2A, TAFII 250, TAFII-250, TAFII250, TAF II P250, TATA box binding protein TBP associated factor RNA polymerase II A, TATA box binding protein TBP associated factor RNA polymerase II A 250kD, TBP associated factor 250 kDa, TBP-associated factor 250 kDa, Transcription factor TFIID p250 polypeptide, Transcription initiation factor TFIID 250 kDa subunit, Transcription initiation factor TFIID subunit 1.
Target Information: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. This gene is part of a complex transcriptional unit (TAF1/DYT3), wherein some products share exons with TAF1 as well as additional exons downstream.[provided by RefSeq, Aug 2009]