Description
Product Characteristics: AXL(Tyrosine-protein kinase receptor UFO) may function as a signal transducer between specific cell types of mesodermal origin. In case of filovirus infection, AXL seems to function as a cell entry factor. AXL is heterodimer and heterotetramer with GAS6. AXL is a single-pass type I membrane protein. It is highly expressed in metastatic colon tumors. And weakly expressed in normal colon tissue. AXL belongs to the protein kinase superfamily and Tyr protein kinase family and AXL/UFO subfamily. AXL contains 1 protein kinase domain.
Synonyms: UFO
Target Information: The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]