Description
Product Characteristics:
RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation.
Subcellular location: Cytoplasm, Nucleus
Synonyms: SEB4D, CLL associated antigen KW 5, CLL-associated antigen KW-5, HSRNASEB, RBM38, RBM38_HUMAN, RNA binding mot protein 38, RNA binding protein 38, RNA binding region RNP1, RRM containing 1, RNA binding region containing protein 1, RNA-binding mot protein 38, RNA-binding protein 38, RNA-binding region-containing protein 1, RNPC1, SEB4, SEB4B, ssDNA binding protein SEB4, ssDNA-binding protein SEB4.
Target Information: RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell- specific isoform of FGFR2 (By similarity). Plays a role in myogenic differentiation