Description
Product Characteristics:
Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA (By similarity). May function as transcriptional coactivator. May modulate the transcription factor activity of THRB.Mainly expressed in tissues that synthesize triglycerides.
Subcellular location: Cytoplasm, Nucleus
Synonyms: Lpgp, LPGP1, S14, S14 protein, SPOT 14, Spot 14 protein, SPOT14, SPOT14 homolog, Thrsp, THRSP_HUMAN, Thyroid hormone inducible hepatic protein, Thyroid hormone responsive SPOT14 homolog rat, Thyroid hormone responsive, Thyroid hormone responsive protein, Thyroid hormone responsive SPOT14, Thyroid hormone-inducible hepatic protein.
Target Information: The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism. [provided by RefSeq, Jul 2008]