Description
Product Characteristics:
Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest. Binds to the consensus sequence 5'-CCCG[GT]ATGT-3'. Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1.
Subcellular location: Nucleus
Synonyms: Cyclin D binding Myb like transcription factor 1, cyclin D binding myb like transcription factor 1D interacting myb like protein, Cyclin D interacting Myb like protein 1, Cyclin-D-binding Myb-like transcription factor 1, Cyclin-D-interacting Myb-like protein 1, D interacting myb like protein, DMP1, DMTF, dmtf1, DMTF1_HUMAN, hDMP1, hDMTF1, mDmp1.
Target Information: This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]