Description
Product Characteristics:
Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.
Subcellular location: Cytoplasm, Nucleus
Synonyms: Adapter protein GRID, GADS, GADS protein, GRAP-2, GRAP2, GRAP2_HUMAN, GRB-2-like protein, GRB2-related adapter protein 2, GRB2-related adaptor protein 2, GRB2-related protein with insert domain, GRB2L, GRBLG, GrbX, Grf-40, Grf40 adapter protein, Grf40, GRID, Growth factor receptor-binding protein, Growth factor receptor-bound protein 2-related adaptor protein 2, GRPL, Hema, Hematopoietic cell-associated adapter protein GrpL, Hematopoietic cell-associated adaptor protein GRPL, Mona, P38 antibody Protein GADS, SH3-SH2-SH3 adapter Mona, SH3-SH2-SH3 adaptor molecule.
Target Information: This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq, Jul 2008]