Description
Product Characteristics:
Fetal ear, skin, and tongue and human cell lines. Highly up-regulated in psoriatic epidermis. Also highly expressed in the urine of bladder squamous cell carcinoma (SCC) bearing patients.
Subcellular location: Cytoplasm, Secreted
Synonyms: HID 5, Protein S100 A7, Protein S100-A7, PSOR 1, PSOR1, Psoriasin 1, Psoriasin, Psoriasin1, S100 Calcium binding protein A7, S100 calcium-binding protein A7, S100A7, S100A7c, S10A7_HUMAN, S100A7A, S100A15.
Target Information: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. This protein is markedly over-expressed in the skin lesions of psoriatic patients, but is excluded as a candidate gene for familial psoriasis susceptibility. The exact function of this protein is not known. [provided by RefSeq, Jul 2008]