Description
Product Characteristics:
The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq].
Subcellular location: Cytoplasm, Nucleus
Synonyms: e 4 gamma 1, e 4G 1, e 4G1, e4G1, E4 gamma, E4F, E4G, E4GI, Eukaryotic translation initiation factor 4 gamma 1, p220, DKFZp686A1451.
Target Information: Please see product details or send an inquiry to antibodies-online for additional target information