Description
Product Characteristics:
MLF1 Interacting protein (also known as PBIP1, MLF1IP1, KLIP1 or KSHV latent nuclear antigen interacting protein 1) is a component of the CENPA nucleosome-associated complex (CENPA NAC), which plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. This protein is involved in transcriptional repression and interacts with the N-terminal domain of Kaposi Sarcoma Herpesvirus latent nuclear antigen (KSHV LNA).
Subcellular location: Cytoplasm, Nucleus
Synonyms: CENP U, CENP50, CENPU, centromere protein U, HHV8 LNAIP1, ICEN24, Kaposi Sarcoma Herpesvirus latent nuclear antigen interacting protein 1, KLIP-1, KLIP1, KLIP 1, KSHV latent nuclear antigen interacting protein 1, KSHV LNAIP1, LNAIP 1, LNAIP-1, MLF1IP1, PBIP1, CENPU_HUMAN.
Target Information: The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). MLF1IP, or CENPU, is an additional factor required for centromere assembly (Foltz et al., 2006 [PubMed 16622419]).[supplied by OMIM, Mar 2008]