Description
Product Characteristics:
ELAC2 is a zinc phosphodiesterase which displays some tRNA 3' processing endonuclease activity. It is thought to be involved in tRNA maturation, acting by removing a 3' trailer from precursor tRNA. ELAC2 also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. A number of allelic variants have been investigated in hereditary prostate cancer.
Subcellular location: Cytoplasm, Nucleus
Synonyms: elaC homolog 2, ElaC homolog protein 2, ELC2, Heredity prostate cancer protein 2, HPC2, putative prostate cancer susceptibility protein HPC2/ELAC2, Ribonuclease Z2, RNase Z2, tRNA 3 endonuclease 2, tRNase Z long form, tRNase Z2, Zinc phosphodiesterase ELAC protein 2.
Target Information: The protein encoded by this gene has a C-terminal domain with tRNA 3' processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]